Review Article
Meta-Analysis: Diagnostic Accuracy of Anti-Cyclic Citrullinated Peptide Antibody for Juvenile Idiopathic Arthritis
Table 2
Summary of subgroup analysis of the included studies by different study characteristics.
| | Variables | Number of studies | SN (95% CI) | SP (95% CI) | +LR (95% CI) | −LR (95% CI) | DOR (95% CI) | AUC |
| | All studies | 17 | 0.10 (0.06–0.15) | 0.99 (0.98–1.00) | 10.05 (3.59–30.07) | 0.91 (0.87–0.96) | 11.00 (3.53–34.23) | 0.96 | | Subtype of patients | | | | | | | | | RF+ PA | 14 | 0.48 (0.31–0.65) | 0.99 (0.98–1.00) | 53.27 (27.78–102.16) | 0.53 (0.38–0.73) | 101.45 (43.74–235.28) | 0.99 | | RF− PA | 11 | 0.06 (0.03–0.11) | 0.99 (0.98–1.00) | 5.26 (1.86–14.92) | 0.95 (0.91–0.99) | 5.53 (1.89–16.19) | 0.99 | | SA | 12 | 0.23 (0.00–0.20) | 0.99 (0.98–1.00) | 2.71 (0.28–26.40) | 0.99 (0.93–1.04) | 2.76 (0.27–28.25) | 0.97 | | OA | 13 | 0.02 (0.08–0.62) | 0.99 (0.98–1.00) | 2.65 (0.81–8.78) | 0.99 (0.96–1.01) | 2.70 (0.80–9.10) | 0.67 | | ERA | 7 | — | — | — | — | — | — | | PsA | 3 | — | — | — | — | — | — | | UA | 2 | — | — | — | — | — | — | | Control group type | | | | | | | | | ORD | 10 | 0.07 (0.04–0.14) | 0.98 (0.94–0.99) | 4.04 (1.05–15.53) | 0.94 (0.89–0.99) | 4.28 (1.06–17.26) | 0.99 | | HC | 13 | 0.09 (0.06–0.15) | 0.99 (0.98–1.00) | 15.51 (4.62–52.07) | 0.91 (0.87–0.96) | 17.00 (4.94–58.52) | 0.99 | | ORD and HC | 7 | 0.09 (0.05–0.16) | 0.99 (0.97–1.00) | 7.59 (2.20–26.20) | 0.92 (0.87–0.98) | 8.22 (2.27–29.73) | 0.99 | | Generation of anti-CCP tests | | | | | | | | | CCP 1 | 2 | — | — | — | — | — | — | | CCP 2 | 11 | 0.10 (0.05–0.18) | 0.99 (0.99-1.00) | 17.51 (4.93–62.24) | 0.91 (0.84–0.97) | 19.28 (5.17–71.94) | 0.99 | | CCP 3 | 4 | — | — | — | — | — | — | | Assay manufacturer | | | | | | | | | Inova | 8 | 0.17 (0.14–0.20) | 0.99 (0.97–1.00) | 15.19 (5.12–45.00) | 0.84 (0.81–0.88) | 18.01 (5.93–54.71) | 0.80 | | Others | 9 | 0.05 (0.02–0.11) | 0.99 (0.98–1.00) | 9.37 (1.78–49.19) | 0.95 (0.91–1.00) | 9.84 (1.80–53.88) | 0.98 |
|
|
SN = sensitivity; SP = specificity; +LR = positive likelihood ratio; −LR = negative likelihood ratio; DOR = diagnostic odds ratio; AUC = area under curve; RF = rheumatoid factor; RF+ PA = RF-positive polyarthritis; RF− PA = RF-negative polyarthritis; SA = systemic-onset arthritis; OA = oligoarthritis; PsA = psoriatic arthritis; ERA = enthesitis-related arthritis; UA = undifferentiated arthritis; ORD = other rheumatic disease; HC = healthy control; CCP = cyclic citrullinated peptides; CCP1 = the first anti-cyclic citrullinated peptides autoantibody tests; CCP2 = the second anti-cyclic citrullinated peptides autoantibody tests; CCP3 = the third anti-cyclic citrullinated peptides autoantibody tests.
|
