Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis

Table 3

Sex hormones serum levels in patients with VKC in remission phase compared to healthy subjects.

	Late puberty
	VKC	Healthy
	6	12
Age
Mean ± SD	14–17	14–17
Range	15.3 ± 1	15.7 ± 1
LH (mUI/mL)
Mean ± SD	2.7 ± 0.6	2.6 ± 1.4
Range	2.1–3.5	1.1–5.4
FSH (mUI/mL)
Mean ± SD	5.8 ± 3.8	5.2 ± 1.5
Range	1.4–8.2	2.9–9.8
Total testosterone (ng/100 mL)
Mean ± SD	369 ± 142	369 ± 142
Range	202–593	254–789
Free testosterone (ng/100 mL)
Mean ± SD		24.8 ± 6.6
Range	202–593	254–789
DHT (pg/mL)
Mean ± SD	362 ± 37	445 ± 89
Range	320–386	289–593
Estradiol (pg/mL)
Mean ± SD	21 ± 9	27 ± 7
Range	15–37	19–41
Estrone (pg/mL)
Mean ± SD		25.5 ± 2.7
Range	27–43	22–30
DHEAS (ng/mL)
Mean ± SD		1783 ± 398
Range	645–2370	1047–2648
D4A (ng/mL)
Mean ± SD	1.4 ± 0.5	1.6 ± 0.3
Range	1–2.2	1.1–2.1
Cortisol (ng/mL)
Mean ± SD	130 ± 63	119 ± 37
Range	56–209	76–203
SHBG (nmol/L)
Mean ± SD		30 ± 9
Range	36–123	13–39

VKC: vernal keratoconjunctivitis; ; : number; SD: standard deviation; LH: luteinizing hormone; FSH: follicle-stimulating hormone; DHT: dihydrotestosterone; DHEAS: dehydroepiandrosterone-sulfate; D4A: delta-4-androstenedione; SHBG: sex hormones binding globulin.