HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response

Figure 5

The HMGB1 levels were associated with proinflammatory cytokines in SLE patients. (a-b) TNF-α (a) and IL-6 (b) concentrations in sera from SLE patients and HC were detected by ELISA. The scatter-plot represented the TNF-α and IL-6 levels by ELISA analysis. Each symbol represents one SLE patient. Horizontal lines represent the median. Data represent the average from experiments performed in triplicates for each patient. (c-d) Correlation analyses were presented between HMGB1 and TNF-α levels (c), HMGB1 and IL-6 levels (d). Pearson correlation analysis was used in the correlation analysis. .

(a)

(b)

(c)

(d)