Journal of Immunology Research / 2015 / Article / Tab 1

Research Article

Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases

Table 1

Comparison of protein concentrations (pg/mL) of growth factors and cytokines between controls and baseline pregnancy samples.

Healthy control ()Pregnancy baseline ()
MedianMin.Max.MedianMin.Max.

Higher in pregnancy
 GROα341.6243.3742.61018.6424.43208<0.001
 PDGF-AA563.8340.9923.710740.62181>ULD<0.001
 TGFα1.8<LLD33.311.72.778.40.002
 EGF24.88.6178.2489.414.615060.003
 PDGF-AB/BB3410.4493748210760.73650>ULD0.005
Higher in controls
 Eotaxin330.9166.365136.89.8136.9<0.001
 sCD40L424.7132.7142329.2015830.004
 IP-10400.2198.61271162.757.8380.70.009
 IL-1714.82.2161.65.5<LLD46.90.03
 IL-67.9<LLD82<LLD<LLD34.30.03
 IL-1321.3<LLD95<LLD<LLD37.30.05
 MCP-1492.6176.91043335.280.510020.05
Nonstatistically significant differences
 IL1-ra81.4<LLD208721<LLD430.40.07
 IFN62.73.417011.81.3221.60.08
 IL-12p705.7<LLD48.60.6<LLD18.90.09
 IL-25<LLD50.80.1<LLD45.70.1
 sIL2-ra<LLD<LLD52.17.2<LLD71.70.1
 VEGF476.45.71399189.5<LLD466.10.1
 IL-12p4048.6<LLD155.72.4<LLD333.80.2
 IL-3<LLD<LLD5.1<LLD<LLD1.40.2
 IL-4<LLD<LLD98.3<LLD<LLD31.10.2
 MCP-310.4<LLD43.815.9<LLD76.50.2
 RANTES6093.61590>ULD22264.81696>ULD0.2
 IFNα247<LLD378.622.85719.30.3
 IL-50.3<LLD1.10.6<LLD1.80.3
 IL-9<LLD<LLD27<LLD<LLD9.90.3
 Fractalkine106.6<LLD215796.8<LLD514.60.4
 MIP-145.1<LLD36650.127.6196.50.4
 TNF0.2<LLD20.5<LLD<LLD36.60.4
 G-CSF25.17.3220.629.26.3619.80.5
 IL-7<LLD<LLD291.3<LLD219.30.5
 IL-812.84.845.210.81.422.80.5
 FGF-228.811.8103.524.75.975.10.6
 GM-CSF94.114.3456.365.723.733370.6
 Il-1<LLD<LLD25.2<LLD<LLD7.10.6
 FLT3-ligand7<LLD84.1<LLD<LLD72.80.7
 IL-15<LLD<LLD11.10.9<LLD12.10.8
 IL-10<LLD<LLD19.1<LLD<LLD17.10.9
 IL-1ra23<LLD34.4<LLD<LLD48.20.9
 MDC/CCL221460.467640491440.8239.136650.9
 MIP-158.911.612951.115.32890.9
 TNF3.8<LLD35.96.40.497.70.9

EGF = epidermal growth factor, FGF-2 = fibroblast growth factor-2, G-CSF = granulocyte colony stimulating factor, GM-CSF = granulocyte macrophage colony stimulating factor, GRO-a = growth-related oncogene alpha, IFN = interferon, IL = interleukin, IL-1ra = IL-1 receptor antagonist, IP-10 = interferon-gamma induced protein 10, MCP = monocyte chemotactic protein, MDC = macrophage-derived chemokine, MIP = macrophage inflammatory protein, PDGF = platelet-derived growth factor, RANTES = regulated on activation, normal T cell expressed and secreted, sCD40L = soluble CD40 ligand, sIL2-ra = soluble IL-2 receptor alpha, TGF-a = transforming growth factor alpha, TNF = tumor necrosis factor, and VEGF = vascular endothelial growth factor.

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