Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages

Figure 6

The percentage of macrophages TLR2⁺ and TLR4⁺ decreases when monocytes are exposed to LAM. CD14⁺ monocytes were incubated with LAM for 24–120 h at 37°C. Representative zebra plots for TLR2 and TLR4 versus CD14 ((a) and (c)). A percentage of TLR2⁺, CD14⁺TLR2⁺, CD14⁻TLR2⁻, TLR4⁺, CD14⁺TLR4⁺, and CD14⁻TLR4⁻ are shown. Data are representative of five independent experiments. Box plot indicates median ± IQR (5–95). , . Kruskal-Wallis and Dunn post hoc tests compared to unexposed MDM.

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