Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages

Figure 7

The percentage of macrophages DC-SIGN⁺, but not MMR⁺, increases when monocytes are exposed to LAM. CD14⁺ monocytes were incubated with LAM for 24–120 h at 37°C. Representative zebra plots for DC-SING and MMR versus CD14 ((a) and (c)). Percentages of DC-SIGN⁺, CD14⁺DC-SIGN⁺, CD14⁻DC-SIGN⁻, MMR⁺, CD14⁺MMR⁺, and CD14⁻MMR⁻ are shown. Data are representative of five independent experiments. Box plot indicates median ± IQR (5–95). , , and . Kruskal-Wallis and Dunn post hoc tests compared to unexposed monocytes () or to unexposed MDM ().

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