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Journal of Immunology Research
Volume 2016, Article ID 1376595, 14 pages
Review Article

The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk

1Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino, Italy
2IRCCS Istituto Giannina Gaslini, Genova, Italy
3Department of Sensory Organs, University of Rome La Sapienza, Italy
4Gran Sasso National Laboratory, INFN, Assergi, L’Aquila, Italy

Received 1 September 2016; Accepted 8 November 2016

Academic Editor: Anil Shanker

Copyright © 2016 Sara Gabrielli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although NK cells are considered part of the innate immune system, a series of evidences has demonstrated that they possess characteristics typical of the adaptive immune system. These NK adaptive features, in particular their memory-like functions, are discussed from an ontogenetic and evolutionary point of view.