The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk

Figure 4

Memory-like NK cell involvement in vaccination. During the rabies virus vaccination (primary exposure), IL-15, IL-12, and IL-18, produced by virus activated dendritic cells (DCs), generate T and long-lived cytokine-activated NK cells. In the postvaccination recall (secondary exposure), IL-15, IL-12, and IL-18 together with IL-2 produced by memory T cells would induce a strong degranulation and an intense IFN-γ secretion by long-lived cytokine-activated NK cells.