Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation
Dietary vitamin did not modify CCR4 or CCR10 expression on Foxp3+ cells from the skin, SDLN, lung, or ADLN. Female offspring born to vitamin D3-replete or vitamin D3-deficient BALB/c mothers were maintained on the vitamin D3-replete (VitD+) or vitamin D3-deficient diets (VitD−) (resp.) until 8 weeks of age. The expression of (a) CCR4 and (b) CCR10 was measured on CD3+CD4+CD25+Foxp3+ cells in the skin, SDLN, lungs, and ADLN, with cells from vitamin D3-replete and vitamin D3-deficient mice shown in blue and black, respectively (unstained = red shaded). Data are representative of two experiments.
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