Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation

Figure 6

Dietary vitamin did not modify CCR4 or CCR10 expression on Foxp3+ cells from the skin, SDLN, lung, or ADLN. Female offspring born to vitamin D₃-replete or vitamin D₃-deficient BALB/c mothers were maintained on the vitamin D₃-replete (VitD+) or vitamin D₃-deficient diets (VitD−) (resp.) until 8 weeks of age. The expression of (a) CCR4 and (b) CCR10 was measured on CD3+CD4+CD25+Foxp3+ cells in the skin, SDLN, lungs, and ADLN, with cells from vitamin D₃-replete and vitamin D₃-deficient mice shown in blue and black, respectively (unstained = red shaded). Data are representative of two experiments.

(a)

(b)