Monocyte Heterogeneity: Consequences for Monocyte-Derived Immune Cells

Figure 2

Proposed increased recruitment and differentiation of monocytes during inflammation. The contribution of monocytes to populations of mature immune cells is dramatically increased in various inflammatory conditions. Populations of immune cells normally not maintained by monocyte influx, such as populations of DCs and macrophages in the lungs, CSN, heart, liver, and kidney, are being provided by monocyte-derived counterparts during inflammation. Intermediate and nonclassical monocytes differentiate into immune cells with features distinctly different from the ones generated from classical monocytes during inflammation.