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Journal of Immunology Research
Volume 2016, Article ID 1583951, 10 pages
http://dx.doi.org/10.1155/2016/1583951
Research Article

Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia

Jia Sun,1,2,3 Junwei Su,1,2,3 Yirui Xie,1,2,3 Michael T. Yin,4 Ying Huang,1,2,3 Lijun Xu,1,2,3 Qihui Zhou,1,2,3 and Biao Zhu1,2,3

1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China
2The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China
3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China
4Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032, USA

Received 8 November 2015; Revised 20 April 2016; Accepted 9 June 2016

Academic Editor: Paola Nistico

Copyright © 2016 Jia Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including clinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated by corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe and nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index, especially levels of LDH (, ), HBDH (, ), and Ferritin (, ). Plasma IL-8 and IL-6 levels were significantly higher in patients with PaO2/FiO2 ≤ 200 mmHg and nonsurvivors than in those with PaO2/FiO2 > 200 mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 ± 1.56, ; 1.11 ± 0.72, ), larger AUC (95% CI 0.781–1.000, ; 95% CI 0.592–0.917, ), and more significantly inverse correlation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for early evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.