Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia

Figure 3

Receiver operating characteristic (ROC) curve analysis of biomarkers in nonsurvivors () and survivors () AIDS PCP. (a) LDH (95% CI 0.675–0.970, ), HBDH (95% CI 0.797–0.989, ), and FeP (95% CI 0.541–0.991, ) showing much higher AUC in nonsurvivors AIDS PCP groups. (b) IL-6 (95% CI 0.547–0.898, ) and IL-8 (95% CI 0.647–0.953, ) showing much higher AUC in nonsurvivors AIDS PCP groups. (c) IL-8/IL-10 (95% CI 0.561–0.963, ) and IL-6/IL-10 (95% CI 0.592–0.917, ) showing much higher AUC in nonsurvivors AIDS PCP groups. (d) Much better six biomarkers’ ROC curves shown together (WBC: white blood cell; LDH: lactate dehydrogenase; HBDH: hydroxybutyrate dehydrogenase; IL: interleukin; MCP-1: monocyte chemoattractant protein 1, and FeP: Ferritin protein).

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