Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation

Figure 1

Interleukin 10 can act on effector cells, dendritic cells, and cytokine-producer T regulatory cells (Tr1). On effector cells, IL-10 exerts an immunosuppressor function. In dendritic cells, IL-10 can favor a tolerogenic phenotype that promotes the production of further IL-10. On Tr1 cells, IL-10 has an activator effect that also favors IL-10 production.