Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice

Figure 1

Ontogenetic development of intestinal dendritic cells subpopulations. Adapted from Guilliams et al. [35] and expanded by findings from Scott et al. [13]. See text for details. Common dendritic cell progenitor (CDP), preplasmacytoid dendritic cell (pre-pDC), precommon dendritic cell (pre-cDC), plasmacytoid dendritic cell (pDC), common dendritic cell (cDC), aldehyde dehydrogenase (ALDH), regulatory T cell (Treg), retinoic acid (RA), and T-helper 17 cell (Th17). Arrows with solid lines represent published data, and arrows with broken lines represent speculative hypotheses with missing final evidence.