CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE

Figure 2

CXCL13 promoted the proliferation of HRMCs. (a) Cells were treated with CXCL13 at 0.5 ng/mL, 10 ng/mL, and 20 ng/mL. 0.5 ng/mL (500 pg/mL) was optimal concentration. (b) With 500 pg/mL CXCL13, the proliferation ability of HRMCs was shown. Both values of CXCL13 versus control and siR + CXCL13 versus CXCL13 were less than 0.05. (c) Cell cycles of HRMCs with CXCL13 for 0 h and 12 h and transfected cells for 12 h were shown. Results indicated that CXCL13 promoted cells to enter S phase. However, the effect was weakened after the silence of CXCR5. .

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