How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?

Figure 1

Sources of IL-22 and possible mechanism of action in hepatoprotection. IL-22 is secreted by activated TH17, TH22, NK, and NKT cells and binds to IL-22R complex (IL-22R1 and IL-10R2) and leads to the signal transduction through JAK-STAT pathway which may involve Jak-1, Tyk-2, and STAT3. STAT3 activation results in hepatoprotection and liver regeneration.