The Polymorphism −308G/A of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection
Table 3
Multivariate analysis for acute rejection in the discovery cohort ().
Variable
OR (95% CI)
value
No thymoglobulin treatment
TNF-α −308 GG
1
TNF-α −308 GA/AA
4.05 (1.76 to 9.28)
0.001
Thymoglobulin treatment
TNF-α −308 GG
1
TNF-α −308 GA/AA
0.65 (0.12 to 3.69)
0.65
TNF-α −308 GG
Thymoglobulin treatment
1
No thymoglobulin treatment
2.72 (1.05 to 7.05)
0.04
TNF-α −308 GA/AA
Thymoglobulin treatment
1
No thymoglobulin treatment
13.74 (1.59 to 118.7)
0.02
Recipient age
≥60 years
1
<60 years
2.29 (1.10 to 4.78)
0.03
Adjusted for recipient sex, donor age and sex, HLA-DR mismatches, and delayed graft function. p-interaction (thymoglobulin treatment and TNF-α −308 polymorphism) = 0.03.
