Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

Figure 1

Reactive intermediates formed by MPO. In the presence of hydrogen peroxide and chloride, bromide, thiocyanate, tyrosine, or nitrite, MPO catalyses the formation of hypochlorous, hypobromous, and hypothiocyanous acids, tyrosyl radical, and reactive nitrogen intermediates. H₂O₂, hydrogen peroxide; Cl⁻, chloride; Br⁻, bromide; SCN⁻, thiocyanate; HOCl, hypochlorous acid; HOBr, hypobromous acid; HOSCN, hypothiocyanous acid.