F4/80⁺ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo

Figure 2

Enlarged spleens in ESHP recipients. (a) Photos of spleens at day 18 after transplant; scale bar = 1 cm. (b) Spleen weights at days 17–34 after transplant for ESHP recipients (CD41 filled triangles (), CD45 filled squares ()), untransplanted NSG (), and whole BMT recipients (). (c) Absolute numbers of donor-derived cells (CD41 (), CD45 ()) and untransplanted NSG (). (d) Absolute numbers of host-derived cells in ESHP recipients (CD41 (), CD45 ()) compared to untransplanted NSG () controls. Bars represent mean ± SEM; ; .

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