Effect of HSV-IL12 Loaded Tumor Cell-Based Vaccination in a Mouse Model of High-Grade Neuroblastoma

Figure 1

Murine IL-12 production in Neuro 2a cell line transduced with M002 virus. Murine IL-12 production was determined in nonirradiated and irradiated (10 Gy) Neuro 2a cell line transduced with M002 at MOI 5 pfu/cell. At 4, 12, and 24 hours after infection, concentrations of murine IL-12 in culture media were determined by ELISA. Data is reported as mean ± standard error of the mean. There was a significant increase in murine IL-12 production in untreated and XRT-treated cells as early as 12 hours after infection.