Journal of Immunology Research / 2016 / Article / Fig 5

Research Article

Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development

Figure 5

Normalized scores for background signal in samples from 15 cynomolgus monkeys across four biotherapeutics. Two samples taken 1 week apart from 15 cynomolgus monkeys were spiked at 5 μg/mL with ADC C, mAb 1, mAb 2, and mAb 4 and analyzed in the generic assay. This figure illustrates the difference in responses for each biotherapeutic spiked in the individual samples. Normalized scores were calculated for each sample as the log (sample signal/negative control signal) across all four molecules.

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