Journal of Immunology Research / 2016 / Article / Fig 8

Research Article

Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development

Figure 8

Good agreement between ADA titers by biotin-DIG ELISA and relative ADA ratios by the plug-and-play assay. The figure summarizes the relative levels of ADA Studies 1 (ADC A and mAb A) and 2 (ADC B and mAb B) whose samples were determined as positive by two ADA methods. The ratios calculated in the plug-and-play assay were plotted versus the titers determined in the biotherapeutic-specific biotin-DIG ELISAs. Overall, good agreement between the two procedures was observed.

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