Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development
Estimation of cut point factor based on different false positive rates (). Cut point factor (CPF) calculated at different false positive rates based on the within monkey variability observed across 4 biotherapeutics. This generic CPF can be used to establish the floating individual cut point signal according to each cynomolgus monkey baseline signal.
Cut point factor
= false positive rate.
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