Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Figure 2

Crystal structure of the HLA-E/KK50.4 TCR complex [12]. (a) Overview of the HLA-E/KK50.4 TCR structure showing two orthogonal views. The HLA-E heavy chain is shown in grey ribbons, the UL40 peptide in pink sticks, and β2m in blue ribbons. The KK50.4 alpha and beta chains are shown as orange and green ribbons, respectively. (b) The convergence of all 3 CDR β loops onto P8 Ile of the peptide bound to HLA-E. The HLA-E heavy chain is grey, peptide is pink, CDR1β is yellow, CDR2β is green, and CDR3β is shown in red.

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