Sequence Origin Description of antigen Patients/donors Recognition by T-cells Reference ? Mycobacterium tuberculosis Glycopeptide from Mpt32 T-cell clones derived from latently infected individuals IFNγ production [31 , 32 ] SLELGDSAL Human TCR Vβ 1 Healthy donors, in vitro priming of CD8+ T-cells Target cell lysis [33 ] LLLGPGSGL TCR Vβ 2 SQAPLPCVL Epstein Barr Virus BZLF1 T-cells from healthy donor; MS patients T-cell proliferation, target cell lysis, TM staining [34 –36 ] VTAPRTVLL Human HLA-B15 T-cell lines from healthy donors T-cell proliferation, target cell lysis [34 ] VMAPRALLL Human HLA-Cw7 VMAPRTLFL Human HLA-G1 VMAPRTLIL Cytomegalovirus UL40 T-cell lines from healthy donors; lung transplant recipients NK-CTL proliferation, target cell lysis, TM staining [12 , 34 , 35 , 37 –42 ] VMAPRTLVL VMAPRTLLL GMQFDRGYL Salmonella enterica serovar typhi S. typhimurium GroELHealthy volunteers vaccinated with S. typhi strain Ty21a Target cell lysis [43 ] AMLQDIATL KMLRGVNVL VEGEALATL AAVEELKAL AVAKAGKPL KLQERVAKL YLLPRRGPRL Hepatitis C Virus Peptide HCV core aa 35–44 Chronic hepatitis C patients IFNγ production [44 ] 69 peptides Mycobacterium tuberculosis Multiple proteins expressed by Mtb Latently infected individuals, BCG vaccinated newborns CD8+ T-cell proliferation [30 ] QMRPVSRVL Human Hsp60sp Healthy donors, patients with type I diabetes T-cell proliferation, target cell lysis [45 ] ? Salmonella enterica serovar typhi ? Healthy volunteers vaccinated with S. typhi strain Ty21a Cytokine producing T-cells [46 ] RMPPLGHEL Mycobacterium tuberculosis Rv2997, alanine rich dehydrogenase T-cell clones derived from latently infected individuals CD137 expression, ZAP70 phosphorylation; CD8+ T-cell proliferation, TNFα production, TM staining [47 , 48 ] VLRPGGHFL Mycobacterium tuberculosis Rv1523, methyltransferase VMTTVLATL Mycobacterium tuberculosis Rv1734c, conserved hypothetical protein Patients with pulmonary TB CD8+ T-cell proliferation, TNFα production, TM staining [48 ] RLPAKAPLL Mycobacterium tuberculosis Rv1484, NADH-dependent enoyl reductase InhA VMATRRNVL Mycobacterium tuberculosis Rv1518, unknown, possibly glycosyl transferase VLRPGGHFL Mycobacterium tuberculosis Rv1523, methyltransferase ? Salmonella typhi ? Healthy donors challenged with Salmonella typhi Cytokine production [49 ]
