Journal of Immunology Research / 2016 / Article / Tab 1

Review Article

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Table 1

Antigen types/characteristics presented in HLA-E and recognized by T-cells.

SequenceOriginDescription of antigenPatients/donorsRecognition by T-cellsReference

?Mycobacterium tuberculosisGlycopeptide from Mpt32T-cell clones derived from latently infected individualsIFNγ production[31, 32]

SLELGDSAL HumanTCR Vβ1Healthy donors, in vitro priming of CD8+ T-cellsTarget cell lysis[33]⁢
LLLGPGSGLTCR Vβ2

SQAPLPCVLEpstein Barr VirusBZLF1T-cells from healthy donor; MS patientsT-cell proliferation, target cell lysis, TM staining[3436]

VTAPRTVLLHumanHLA-B15T-cell lines from healthy donorsT-cell proliferation, target cell lysis[34]⁢
VMAPRALLLHumanHLA-Cw7
VMAPRTLFLHumanHLA-G1

VMAPRTLILCytomegalovirusUL40T-cell lines from healthy donors; lung transplant recipientsNK-CTL proliferation, target cell lysis, TM staining[12, 34, 35, 3742]
VMAPRTLVL
VMAPRTLLL

GMQFDRGYLSalmonella enterica serovar typhiS. typhimurium GroELHealthy volunteers vaccinated with S. typhi strain Ty21aTarget cell lysis[43]⁢
AMLQDIATL
KMLRGVNVL
VEGEALATL
AAVEELKAL
AVAKAGKPL
KLQERVAKL

YLLPRRGPRLHepatitis C VirusPeptide HCV core aa 35–44Chronic hepatitis C patientsIFNγ production[44]

69 peptidesMycobacterium tuberculosisMultiple proteins expressed by MtbLatently infected individuals, BCG vaccinated newbornsCD8+ T-cell proliferation[30]

QMRPVSRVLHumanHsp60spHealthy donors, patients with type I diabetesT-cell proliferation, target cell lysis[45]

?Salmonella enterica serovar typhi?Healthy volunteers vaccinated with S. typhi strain Ty21aCytokine producing T-cells[46]

RMPPLGHELMycobacterium tuberculosisRv2997, alanine rich dehydrogenaseT-cell clones derived from latently infected individualsCD137 expression, ZAP70 phosphorylation; CD8+ T-cell proliferation, TNFα production, TM staining[47, 48]
VLRPGGHFLMycobacterium tuberculosisRv1523, methyltransferase

VMTTVLATLMycobacterium tuberculosisRv1734c, conserved hypothetical proteinPatients with pulmonary TBCD8+ T-cell proliferation, TNFα production, TM staining[48] ⁢
RLPAKAPLLMycobacterium tuberculosisRv1484, NADH-dependent enoyl reductase InhA
VMATRRNVLMycobacterium tuberculosisRv1518, unknown, possibly glycosyl transferase
VLRPGGHFLMycobacterium tuberculosisRv1523, methyltransferase

?Salmonella typhi?Healthy donors challenged with Salmonella typhiCytokine production[49]

D. Lewinsohn, personal communication, manuscript in preparation.

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