Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Table 1

Antigen types/characteristics presented in HLA-E and recognized by T-cells.

Sequence	Origin	Description of antigen	Patients/donors	Recognition by T-cells	Reference
?	Mycobacterium tuberculosis	Glycopeptide from Mpt32	T-cell clones derived from latently infected individuals	IFNγ production	[31, 32]
SLELGDSAL	Human	TCR Vβ1	Healthy donors, in vitro priming of CD8^+ T-cells	Target cell lysis	[33]⁢
LLLGPGSGL		TCR Vβ2
SQAPLPCVL	Epstein Barr Virus	BZLF1	T-cells from healthy donor; MS patients	T-cell proliferation, target cell lysis, TM staining	[34–36]
VTAPRTVLL	Human	HLA-B15	T-cell lines from healthy donors	T-cell proliferation, target cell lysis	[34]⁢
VMAPRALLL	Human	HLA-Cw7
VMAPRTLFL	Human	HLA-G1
VMAPRTLIL	Cytomegalovirus	UL40	T-cell lines from healthy donors; lung transplant recipients	NK-CTL proliferation, target cell lysis, TM staining	[12, 34, 35, 37–42]
VMAPRTLVL
VMAPRTLLL
GMQFDRGYL	Salmonella enterica serovar typhi	S. typhimurium GroEL	Healthy volunteers vaccinated with S. typhi strain Ty21a	Target cell lysis	[43]⁢
AMLQDIATL
KMLRGVNVL
VEGEALATL
AAVEELKAL
AVAKAGKPL
KLQERVAKL
YLLPRRGPRL	Hepatitis C Virus	Peptide HCV core aa 35–44	Chronic hepatitis C patients	IFNγ production	[44]
69 peptides	Mycobacterium tuberculosis	Multiple proteins expressed by Mtb	Latently infected individuals, BCG vaccinated newborns	CD8^+ T-cell proliferation	[30]
QMRPVSRVL	Human	Hsp60sp	Healthy donors, patients with type I diabetes	T-cell proliferation, target cell lysis	[45]
?	Salmonella enterica serovar typhi	?	Healthy volunteers vaccinated with S. typhi strain Ty21a	Cytokine producing T-cells	[46]
RMPPLGHEL	Mycobacterium tuberculosis	Rv2997, alanine rich dehydrogenase	T-cell clones derived from latently infected individuals	CD137 expression, ZAP70 phosphorylation; CD8^+ T-cell proliferation, TNFα production, TM staining	[47, 48]
VLRPGGHFL	Mycobacterium tuberculosis	Rv1523, methyltransferase
VMTTVLATL	Mycobacterium tuberculosis	Rv1734c, conserved hypothetical protein	Patients with pulmonary TB	CD8^+ T-cell proliferation, TNFα production, TM staining	[48] ⁢
RLPAKAPLL	Mycobacterium tuberculosis	Rv1484, NADH-dependent enoyl reductase InhA
VMATRRNVL	Mycobacterium tuberculosis	Rv1518, unknown, possibly glycosyl transferase
VLRPGGHFL	Mycobacterium tuberculosis	Rv1523, methyltransferase
?	Salmonella typhi	?	Healthy donors challenged with Salmonella typhi	Cytokine production	[49]

D. Lewinsohn, personal communication, manuscript in preparation.