CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity

Figure 2

The cellular trafficking of CD1 molecules. After synthesis, CD1 molecules associate with β2-microglobulin in the endoplasmic reticulum. Then, they traffic to the trans-Golgi network, where they are glycosylated and follow to the plasma membrane (solid arrows). There, CD1 molecules are internalized by the endocytic pathway, where most of the loading occurs. The different CD1 isoforms localize in different endocytic compartments. The loaded CD1 molecules then traffic to the plasma membrane, where they activate T cells (dashed arrows). EE: early endosome; LE: late endosome; hCD1d: human CD1d; mCD1d: mouse CD1d.