CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity

Table 2

Main iNKT cell subsets in mice: transcriptional programs, surface markers, cytokine production, and frequency.

	Transcriptional factors	Surface markers	Cytokine production	Frequency
NKT1	T-bet	NK1.1	IFN-γ	Most frequent subset
	GATA-3	IL-17RB^−	IL-4
	PLZF^−	IL-15Rα^+
	Id2^+	CD4^+/−
NKT2	T-bet	NK1.1^−	IL-4	More common in the lung
	GATA-3	IL-17RB^+	IL-13
	PLZF	CD4^+
	Id3^+
NKT17	RORγt^+	NK1.1^−	IL-17	Mainly present in the lung, lymph nodes, and skin
	PLZF	IL-17RB^+	IL-22
		CD4^−

In C57BL/6 mice. hi: high; lo: low.