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Journal of Immunology Research
Volume 2016 (2016), Article ID 2932531, 8 pages
Review Article

The Role of γδ T Cells in Systemic Lupus Erythematosus

Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China

Received 3 November 2015; Accepted 13 January 2016

Academic Editor: Baojun Zhang

Copyright © 2016 Meng Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the overproduction of autoantibodies against an array of nuclear and cytoplasmic antigens and affects multiple organs, such as the skin, joints, kidneys, and neuronal tissues. T cells have been recognized as important players in the development of SLE due to their functions in cytokine secretion, antigen presentation, and supporting B cells for antibody production. T cells are a minor population of T cells that play important roles in infection and tumor-associated disease. In recent years, the role of T cells in autoimmune diseases has been investigated. In this review, we discussed the role of T cells in the pathogenesis of SLE.