Immunomodulatory Effects Mediated by Dopamine

Table 2

Dopaminergic system protein components expressed in immune system.

Receptors of DRs	Genes names	References
D(1) receptor: D1R; (old name D1A receptor); D1-like subtype	DRD1	[75–87]
D(2) receptor longer: D2R; D2-like subtype	DRD2	[75, 76, 78–80, 82–93]
D(3) receptor: D3R; D2-like subtype	DRD3	[75, 78, 79, 82–90, 92–98]
D(4) receptor: D4R; D2-like subtype	DRD4	[79, 82–88, 92–94, 96, 98–100]
D(5) receptor: D5R; (old name D1B receptor); D1-like subtype	DRD5	[75, 78, 79, 82–88, 90, 92, 93, 98, 101, 102]
Sodium-dependent dopamine transporter: DAT	SLC6A3 (synonyms: DAT1)	[78, 79, 91, 103–105, 115, 116]
Protein components shared with other monoamines systems
Chromaffin granule amine transporter: VAT1	SLC18A1 isoform 2; (synonyms: VMAT1)	[83, 103, 117, 118]
Synaptic vesicular amine transporter: VAT2	SLC18A2 (synonyms: VMAT2)	[75, 79, 83, 103, 116]
Protein components with unknown functions
Chromaffin granule amine transporter: VAT1Δ15	SLC18A1 isoform 2; (synonyms: VMAT1Δ15)	[117, 118]
Pseudogene D(5) receptor	DRD5-1	[101, 119–121]
Pseudogene D(5) receptor	DRD5-2	[101, 119–121]

This gene expresses low levels of mRNA and translates low quantities of the protein.
Unknown peptide product but produces mRNA with unknown functions.
This protein cannot transport serotonin.