Immunomodulatory Effects Mediated by Dopamine

Table 4

Pathology-associated dopaminergic protein expression in immune cells.

Pathology/condition	DA receptors and cell types involved	Reference
Parkinson disease; Patients/MPTP mice	D3R in lymphocytes	[127]
Lesch-Nyhan disease	D5R in lymphocytes	[128]
Multiple sclerosis	D5R in lymphocytes	[129]
Multiple sclerosis treatment with IFN-β	D5R in lymphocytes; D2R in lymphocytes	[129, 130]
Schizophrenia	D4R in T CD8^+ and T CD4^+ lymphocytes; D4R in T CD8^+ lymphocytes; D2R in T CD4^+ lymphocytes	[131]
Rheumatoid arthritis; type II collagen-induced; arthritis (mice)	D2R in lymphocytes	[132]
Rheumatoid arthritis and; osteoarthritis	D5R in B cells; D2R & D3R in B cells	[133]
Systemic lupus erythematosus	D4R in lymphocytes; D2R in lymphocytes	[134]
Alcohol dependence syndrome	D4R in lymphocytes	[135]
Alcohol withdrawal	D1R in lymphocytes	[136]
Computer game addicts	D5R in lymphocytes	[137]