Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation

Figure 5

Ligation of OX40L and OX40 promotes the differentiation of Th2 cells. (a) Western blot revealed the expression of OX40L in BMMCs and their exosomes, but a lower expression on exosomes; (b) flow cytometry showed that naive CD4⁺ T cells expressed OX40; (c) Th2 expression in all the T cells was expressed as mean ± SD. , compared with blank control, . , compared with exosome group, . The results represented three independent experiments. (d–f) Addition of anti-OX40L Ab significantly but partially inhibited the differentiation of Th2 cells positive for IL-4.

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