Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection

Table 1

Prognostic HLA-G biomarker of symptomatic congenital HCMV infection.

Parameters	Cutoff		Fetuses		Diagnostic accuracy				AUA
					95% CI
			Sympt	Asympt	Sens%	Spec%	PPV%	NPV%
Maternal serum samples
HLA-G free-heavy chain		Presence	0	0	0	100	0	29.4	0.5
		Absence	12	5	0–26.7	47.9–100		10.4–55.9
sHLA-G	50 ng/mL	Above	10	0	83.3	100	100	71.4	0.83
		Below	2	5	51.6–97.4	47.9–100	68.9–100	29.3–95.5
Amniotic fluid samples
HLA-G free-heavy chain		Presence	12	3	100	40	80	100	0.79
		Absence	0	2	73.3–100	6.4–84.6	51.9–95.4	19.2–100
sHLA-G	30 ng/mL	Above	11	0	91.7	100	100	83.3	0.86
		Below	1	5	61.5–98.6	47.9–100	71.3–100	36.1–97.2

Sens: sensitivity; Spec: specificity; PPV: positive predictive value; NPV: negative predictive value; AUA: Area Under an ROC Curve; Sympt: symptomatic; Asympt: asymptomatic.