Review Article
Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
Table 1
Summary of current phenotypes described for different DC subsets.
| | DC type | Phenotype/markers | Function | Reference |
| | Plasmacytoid DC (pDC) | MHC-II, CD45RA/B220,
Ly6C/GR-1, Siglec-H | Type I-IFN synthesis | [11–13] | | Conventional DC type 1 (cDC1) | CD8α, CD103 (mice);
CD141/BDCA3 (humans) | Antigen cross-presentation, CD8α+ T cell activation | [15, 16, 18, 19] | | Conventional DC type 2 (cDC2) | CD11b, CD172/SIRPα (mice);
CD1c/BDCA1 (humans) | CD4+ T cell polarization | [17, 20, 21] | | Monocyte-derived DC (MoDC) | CD11c, MHC-II, F4/80, CD64 (mice); CD1a (humans) | Antigen presentation at inflammatory sites | [23, 24] | | Langerhans cell (LC) | MHC-II, Langerin | Antigen presentation in the skin | [25–27] |
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