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Journal of Immunology Research
Volume 2016, Article ID 3969023, 8 pages
http://dx.doi.org/10.1155/2016/3969023
Review Article

Gq-Coupled Receptors in Autoimmunity

1Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China
2Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China

Received 6 October 2015; Accepted 27 December 2015

Academic Editor: Xiao-Feng Yang

Copyright © 2016 Lu Zhang and Guixiu Shi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. B. Hubbard and J. R. Hepler, “Cell signalling diversity of the Gqα family of heterotrimeric G proteins,” Cellular Signalling, vol. 18, no. 2, pp. 135–150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. Naor, “Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor,” Frontiers in Neuroendocrinology, vol. 30, no. 1, pp. 10–29, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Sisley, R. Doherty, and N. A. Cross, “What hope for the future? GNAQ and uveal melanoma,” The British Journal of Ophthalmology, vol. 95, no. 5, pp. 620–623, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. R. Neves, P. T. Ram, and R. Iyengar, “G protein pathways,” Science, vol. 296, no. 5573, pp. 1636–1639, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Wettschureck, A. Moers, and S. Offermanns, “Mouse models to study G-protein-mediated signaling,” Pharmacology & Therapeutics, vol. 101, no. 1, pp. 75–89, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Mizuno and H. Itoh, “Functions and regulatory mechanisms of Gq-signaling pathways,” Neuro-Signals, vol. 17, no. 1, pp. 42–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Sánchez-Fernández, S. Cabezudo, C. García-Hoz et al., “Gαq signalling: the new and the old,” Cellular Signalling, vol. 26, no. 5, pp. 833–848, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Kawakami and W. Xiao, “Phospholipase C-β in immune cells,” Advances in Biological Regulation, vol. 53, no. 3, pp. 249–257, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. Lyon, V. G. Taylor, and J. J. G. Tesmer, “Strike a pose: Gαq complexes at the membrane,” Trends in Pharmacological Sciences, vol. 35, no. 1, pp. 23–30, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Mishra, H. Ling, M. Grimm, T. Zhang, D. M. Bers, and J. H. Brown, “Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling,” Journal of Cardiovascular Pharmacology, vol. 56, no. 6, pp. 598–603, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Fišerová, M. Starec, M. Kuldová et al., “Effects of D2-dopamine and α-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice,” Journal of Neuroimmunology, vol. 130, no. 1-2, pp. 55–65, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. S.-M. Lee, Y. Yang, and R. B. Mailman, “Dopamine D1receptor signaling: Does GαQ-phospholipase C actually play a role?” The Journal of Pharmacology and Experimental Therapeutics, vol. 351, no. 1, pp. 9–17, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. B. A. Wilson and M. Ho, “Pasteurella multocida toxin as a tool for studying Gq signal transduction,” Reviews of Physiology, Biochemistry and Pharmacology, vol. 152, pp. 93–109, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. R. S. Misra, G. Shi, M. E. Moreno-Garcia et al., “Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity,” Journal of Experimental Medicine, vol. 207, no. 8, pp. 1775–1789, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Ngai, T. Methi, K. W. Andressen et al., “The heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway,” European Journal of Immunology, vol. 38, no. 11, pp. 3208–3218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Svensson, P. Stanley, F. Willenbrock, and N. Hogg, “The Galphaq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recycling,” PLoS ONE, vol. 7, no. 6, Article ID e38517, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Wang, Y. Zhang, Y. He, Y. Li, F. E. Lund, and G. Shi, “The deficiency of Gαq leads to enhanced T-cell survival,” Immunology and Cell Biology, vol. 92, no. 9, pp. 781–790, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Wang, Y. Li, and G. Shi, “The regulating function of heterotrimeric G proteins in the immune system,” Archivum Immunologiae et Therapiae Experimentalis, vol. 61, no. 4, pp. 309–319, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Antonelli, S. M. Ferrari, D. Giuggioli, E. Ferrannini, C. Ferri, and P. Fallahi, “Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases,” Autoimmunity Reviews, vol. 13, no. 3, pp. 272–280, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Carvalho, S. L. Calvisi, B. Leal et al., “CCR5-Delta32: implications in SLE development,” International Journal of Immunogenetics, vol. 41, no. 3, pp. 236–241, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Y. Choi, J. H. Ho, S. G. Pasoto et al., “Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity,” Arthritis & Rheumatology, vol. 67, no. 4, pp. 988–999, 2015. View at Publisher · View at Google Scholar
  22. G. S. Firestein, “Evolving concepts of rheumatoid arthritis,” Nature, vol. 423, no. 6937, pp. 356–361, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. J. D. Jacobson, “Gonadotropin-releasing hormone and G proteins: potential roles in autoimmunity,” Annals of the New York Academy of Sciences, vol. 917, pp. 809–818, 2000. View at Google Scholar · View at Scopus
  24. Y. Li, Y. Wang, Y. He et al., “Gαq gene promoter polymorphisms and rheumatoid arthritis in the Han Chinese population are not associated,” Genetics and Molecular Research, vol. 12, no. 2, pp. 1841–1848, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Stanislaus, J. H. Pinter, J. A. Janovick, and P. M. Conn, “Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone,” Molecular and Cellular Endocrinology, vol. 144, no. 1-2, pp. 1–10, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. J. D. Jacobson, M. A. Ansari, M. Kinealy, and V. Muthukrishnan, “Gender-specific exacerbation of murine lupus by gonadotropin-releasing hormone: potential role of Gα(q/11),” Endocrinology, vol. 140, no. 8, pp. 3429–3437, 1999. View at Google Scholar · View at Scopus
  27. M. A. Ansari, M. Dhar, V. Muthukrishnan, T. L. Morton, N. Bakht, and J. D. Jacobson, “Administration of antisense oligonucleotides to GαQ/11 reduces the severity of murine lupus,” Biochimie, vol. 85, no. 6, pp. 627–632, 2003. View at Publisher · View at Google Scholar
  28. J. D. Jacobson, L. J. Crofford, L. Sun, and R. L. Wilder, “Cyclical expression of GnRH and GnRH receptor mRNA in lymphoid organs,” Neuroendocrinology, vol. 67, no. 2, pp. 117–125, 1998. View at Publisher · View at Google Scholar · View at Scopus
  29. T. L. Morton, M. A. Ansari, and J. D. Jacobson, “Gender differences and hormonal modulation of G proteins Gαq/11 expression in lymphoid organs,” Neuroendocrinology, vol. 78, no. 3, pp. 147–153, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. P. E. Micevych, J. Kuo, and A. Christensen, “Physiology of membrane oestrogen receptor signalling in reproduction,” Journal of Neuroendocrinology, vol. 21, no. 4, pp. 249–256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. V. Rider and N. I. Abdou, “Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus,” International Immunopharmacology, vol. 1, no. 6, pp. 1009–1024, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Arai and I. F. Charo, “Differential regulation of G-protein-mediated signaling by chemokine receptors,” The Journal of Biological Chemistry, vol. 271, no. 36, pp. 21814–21819, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Liu and G. Shi, “Role of G protein-coupled receptors in control of dendritic cell migration,” BioMed Research International, vol. 2014, Article ID 738253, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. C. A. Flanagan, “Receptor conformation and constitutive activity in CCR5 chemokine receptor function and HIV infection,” Advances in Pharmacology, vol. 70, pp. 215–263, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Henneken, T. Dörner, G.-R. Burmester, and C. Berek, “Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus,” Arthritis Research & Therapy, vol. 7, no. 5, pp. R1001–R1013, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. O. Launay, S. Paul, A. Servettaz et al., “Control of humoral immunity and auto-immunity by the CXCR4/CXCL12 axis in lupus patients following influenza vaccine,” Vaccine, vol. 31, no. 35, pp. 3492–3501, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. C. K. Wong, P. T. Y. Wong, L. S. Tam, E. K. Li, D. P. Chen, and C. W. K. Lam, “Elevated production of B Cell Chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity,” Journal of Clinical Immunology, vol. 30, no. 1, pp. 45–52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Shi, S. Partida-Sánchez, R. S. Misra et al., “Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes,” The Journal of Experimental Medicine, vol. 204, no. 11, pp. 2705–2718, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Bidyalaxmi Devi, A. Bhatnagar, A. Wanchu, and A. Sharma, “A study on the association of autoantibodies, chemokine, and its receptor with disease activity in systemic lupus erythematosus in North Indian population,” Rheumatology International, vol. 33, no. 11, pp. 2819–2826, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. C. R. Mackay, “Moving targets: cell migration inhibitors as new anti-inflammatory therapies,” Nature Immunology, vol. 9, no. 9, pp. 988–998, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Trujillo, A. J. Hartigan, and C. M. Hogaboam, “T regulatory cells and attenuated bleomycin-induced fibrosis in lungs of CCR7−/− mice,” Fibrogenesis & Tissue Repair, vol. 3, article 18, 2010. View at Publisher · View at Google Scholar
  42. J. Ngai, M. Inngjerdingen, T. Berge, and K. Tasken, “Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation,” BMC Immunology, vol. 10, article 27, 2009. View at Google Scholar
  43. M. Platten, S. Youssef, E. M. Hur et al., “Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 35, pp. 14948–14953, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Rodríguez-Iturbe, H. Pons, Y. Quiroz, and R. J. Johnson, “The immunological basis of hypertension,” American Journal of Hypertension, vol. 27, no. 11, pp. 1327–1337, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. S. Nag and S. S. Mokha, “Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat,” Neuroscience, vol. 267, pp. 122–134, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. L. Yan, X. Tan, W. Chen, H. Zhu, J. Cao, and H. Liu, “Enhanced vasoconstriction to α1 adrenoceptor autoantibody in spontaneously hypertensive rats,” Science China Life Sciences, vol. 57, no. 7, pp. 681–689, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. Y. H. Lee, J.-H. Kim, and G. G. Song, “Chemokine receptor 5 Delta32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren's syndrome. Meta-analysis of possible associations,” Zeitschrift für Rheumatologie, vol. 73, no. 9, pp. 848–855, 2014. View at Publisher · View at Google Scholar · View at Scopus
  48. B. Molon, G. Gri, M. Bettella et al., “T cell costimulation by chemokine receptors,” Nature Immunology, vol. 6, no. 5, pp. 465–471, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. J. P. Hapgood, H. Sadie, W. van Biljon, and K. Ronacher, “Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes,” Journal of Neuroendocrinology, vol. 17, no. 10, pp. 619–638, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. J. H. Kehrl and S. Sinnarajah, “RGS2: a multifunctional regulator of G-protein signaling,” The International Journal of Biochemistry & Cell Biology, vol. 34, no. 5, pp. 432–438, 2002. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Patke, I. Mecklenbräuker, H. Erdjument-Bromage, P. Tempst, and A. Tarakhovsky, “BAFF controls B cell metabolic fitness through a PKCβ- and Akt-dependent mechanism,” The Journal of Experimental Medicine, vol. 203, no. 11, pp. 2551–2562, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. R. K. Bommakanti, S. Vinayak, and W. F. Simonds, “Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits,” The Journal of Biological Chemistry, vol. 275, no. 49, pp. 38870–38876, 2000. View at Publisher · View at Google Scholar · View at Scopus
  53. L. M. Ballou, Y.-P. Jiang, G. Du, M. A. Frohman, and R. Z. Lin, “Ca2+- and phospholipase D-dependent and -independent pathways activate mTOR signaling,” FEBS Letters, vol. 550, no. 1–3, pp. 51–56, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. L. M. Ballou, H.-Y. Lin, G. Fan, Y.-P. Jiang, and R. Z. Lin, “Activated Gαq inhibits p110α phosphatidylinositol 3-kinase and Akt,” The Journal of Biological Chemistry, vol. 278, no. 26, pp. 23472–23479, 2003. View at Publisher · View at Google Scholar · View at Scopus
  55. A. L. Howes, J. F. Arthur, T. Zhang et al., “Akt-mediated cardiomyocyte survival pathways are compromised by Gαq-induced phosphoinositide 4,5-bisphosphate depletion,” The Journal of Biological Chemistry, vol. 278, no. 41, pp. 40343–40351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. M. R. Morissette, A. L. Howes, T. Zhang, and J. H. Brown, “Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes,” Journal of Molecular and Cellular Cardiology, vol. 35, no. 10, pp. 1217–1227, 2003. View at Publisher · View at Google Scholar · View at Scopus
  57. J. S. Gutkind and S. Offermanns, “A new Gq-initiated MAPK signaling pathway in the heart,” Developmental Cell, vol. 16, pp. 163–164, 2009. View at Publisher · View at Google Scholar
  58. S. L. Pogue, T. Kurosaki, J. Bolen, and R. Herbst, “B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase,” Journal of Immunology, vol. 165, no. 3, pp. 1300–1306, 2000. View at Publisher · View at Google Scholar · View at Scopus
  59. R. Kumar, S. Srinivasan, S. Koduru et al., “Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells,” Cancer Prevention Research, vol. 2, no. 3, pp. 234–243, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. C. D. Browne, C. J. Del Nagro, M. H. Cato, H. S. Dengler, and R. C. Rickert, “Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy,” Immunity, vol. 31, no. 5, pp. 749–760, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. A. N. Anzelon, H. Wu, and R. C. Rickert, “Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function,” Nature Immunology, vol. 4, no. 3, pp. 287–294, 2003. View at Publisher · View at Google Scholar · View at Scopus
  62. T. Wu and C. Mohan, “The AKT axis as a therapeutic target in autoimmune diseases,” Endocrine, Metabolic & Immune Disorders Drug Targets, vol. 9, no. 2, pp. 145–150, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. J.-Y. Choe, S.-J. Lee, S.-H. Park, and S.-K. Kim, “Tacrolimus (FK506) inhibits interleukin-1β-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes,” Joint Bone Spine, vol. 79, no. 2, pp. 137–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. H. Cramer, K. Schmenger, K. Heinrich et al., “Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and Gαq,” The FEBS Journal, vol. 268, no. 20, pp. 5449–5459, 2001. View at Publisher · View at Google Scholar
  65. G. Cui, X. Qin, Y. Zhang, Z. Gong, B. Ge, and Y. Q. Zang, “Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice,” The Journal of Biological Chemistry, vol. 284, no. 41, pp. 28420–28429, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. C. Dong, R. J. Davis, and R. A. Flavell, “MAP kinases in the immune response,” Annual Review of Immunology, vol. 20, pp. 55–72, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. D. M. Fuller, M. Zhu, S. Koonpaew, M. I. Nelson, and W. Zhang, “The importance of the erk pathway in the development of linker for activation of T cells-mediated autoimmunity,” Journal of Immunology, vol. 189, no. 8, pp. 4005–4013, 2012. View at Publisher · View at Google Scholar · View at Scopus
  68. A. Mavropoulos, T. Orfanidou, C. Liaskos et al., “p38 Mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: lessons to learn from ANCA vasculitis and pemphigus vulgaris,” Autoimmunity Reviews, vol. 12, no. 5, pp. 580–590, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. A. Mavropoulos, T. Orfanidou, C. Liaskos et al., “P38 MAPK signaling in pemphigus: implications for skin autoimmunity,” Autoimmune Diseases, vol. 2013, Article ID 728529, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. R. Noubade, D. N. Krementsov, R. Del Rio et al., “Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis,” Blood, vol. 118, no. 12, pp. 3290–3300, 2011. View at Publisher · View at Google Scholar · View at Scopus
  71. R. Wei, L. Dong, Q. Xiao, D. Sun, X. Li, and H. Nian, “Engagement of Toll-like receptor 2 enhances interleukin (IL)-17+ autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells,” Clinical and Experimental Immunology, vol. 178, no. 2, pp. 353–363, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. Y. Liu, D. Wang, F. Li, and G. Shi, “Gαq controls rheumatoid arthritis via regulation of Th17 differentiation,” Immunology and Cell Biology, vol. 93, no. 7, pp. 616–624, 2015. View at Publisher · View at Google Scholar
  73. M. E. Csete and J. C. Doyle, “Reverse engineering of biological complexity,” Science, vol. 295, no. 5560, pp. 1664–1669, 2002. View at Publisher · View at Google Scholar · View at Scopus
  74. Y. Wang, Y. Li, Y. He et al., “Expression of G protein αq subunit is decreased in lymphocytes from patients with rheumatoid arthritis and is correlated with disease activity,” Scandinavian Journal of Immunology, vol. 75, no. 2, pp. 203–209, 2012. View at Publisher · View at Google Scholar · View at Scopus