Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model

Figure 2

Overview of scatter and volcano plot of expression of 84 genes in temporoparietal cortex-hippocampus using RT² Profiler PCR array. ((a) and (b)) Rats with chronic administration of zinc (CZn15 d). ((c) and (d)) Rats with chronic administration of zinc before CCAO and evaluations at 8 h after reperfusion (Zn15 d+CCAO 8 h). ((e) and (f)) Rats with chronic administration of zinc before CCAO and evaluations at 7 days after reperfusion (Zn15 d+CCAO 7 d). The experimental values were compared with those of untreated rats. The black line indicates fold changes for scatter plot ((a), (c), and (e)) and (fold difference against value) in the volcano plot ((b), (d), and (f)). The pink lines indicate the desired fold change in gene expression threshold. Each value represents the mean of 3 independent experiments. Arrow shows values with high significance.

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