A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?

Table 3

Immunohistochemistry results for elastogenesis and degradation markers in anetoderma lesional dermis according to clinical phenotype.

	Intensity of immunostaining
	0	+	++	+++	total
Elastin
Protruding type	2	10	5	0	17
Indented type	1	3	6	0	10
Control	0	0	5	0	5
Fibrillin
Protruding type	8	9	0	0	17
Indented type	1	8	0	0	9
Control	0	1	4	0	5
MMP2
Protruding type	12	2	3	0	17
Indented type	2	5	3	0	10
Control	3	2	0	0	5
MMP9
Protruding type	10	3	4	0	17
Indented type	5	2	3	0	10
Control	5	0	0	0	5
TIMP1
Protruding type	10	2	5	0	17
Indented type	5	3	2	0	10
Control	0	2	3	0	5
TIMP2
Protruding type	9	0	1	0	10
Indented type	7	2	0	0	9
Control	4	1	0	0	5

The degree of expression was graded as follows: 0, 0% positive; +, 1–19% positive; ++, 20–79% positive; +++, 80–100% positive.