Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Table 4

Novel findings on HLA-G and infectious diseases.

Type of disease	Observation	Correlation with clinical outcome	Author
Toxoplasmosis	Toxoplasma increased the release of sHLA-G by trophoblast inducing apoptosis of dNK cells	Positive correlation with abnormal pregnancy	Han et al. [71]
Malaria	Higher sHLA-G levels in cord blood are related to low weight at birth and clinical outcome	Positive correlation with high risk of infection in infancy	Sadissou et al. [72]
Pseudomonas aeruginosa	P. aeruginosa induced HLA-G expression in monocytes and T cells protecting from immune response	—	Bortolotti et al. [73]
Pseudomonas aeruginosa	sHLA-G levels are decreased during antibiotic therapy in patients with cystic fibrosis	Negative correlation with inflammation	Rizzo et al. [74]
Helicobacter pylori	HLA-G expression correlated with milder colonization and milder inflammation	Negative correlation with inflammation	Oliveira Souza et al. [75]
HCV	Higher levels of sHLA-G and IL-10 in patients nonresponding to therapy with IFN	Negative correlation with response to therapy	Khorrami et al. [44]
HBV	Patients with 14 bp ins/ins genotype have higher levels of HBV activity and HBV DNA copies	Positive correlation with worse clinical outcome	Laaribi et al. [76]