Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Table 5

Novel findings on HLA-G and transplantation.

Type of transplant	Observation	Correlation with clinical outcome	Author
Kidney	Higher HLA-G5/G6 levels in ESRD and lower levels of HLA-G5 in acute rejection	Negative correlation of HLA-G5 with rejection	Misra et al. [77]
Lung	Higher levels of sHLA-G in bronchoalveolar lavage from patients with acute rejection	Positive correlation with high risk of rejection	White et al. [78]
Lung	Expression of HLA-G in lung protected from CLAD and associated with graft acceptance	Positive correlation with graft acceptance	Brugière et al. [79]
Lung	Two haplotypes of HLA-G gene are associated with lower levels of sHLA-G	Positive correlation with worse long term survival	Di Cristofaro et al. [80]
Murine model	CD4^+HLA-G^+ regulatory T cells produce IL-10, sHLA-G, and IL-35 and ameliorated GvHD	—	Pankratz et al. [81]