Review Article
Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling
Table 2
Negative regulators of TLR signaling involved in ubiquitination.
| E3 ligase or adapter of E3 ligase complex | Target molecules | Ubiquitin-mediated modifications | Biological function |
| A20 | RIP1, Ubc13 | K48 | Proteolytic degradation | Triad3A/RNF216 | TLR3, TLR4, TLR5, TLR9, TIRAP, TRIP, RIP1 | K48 | Proteolytic degradation | SOCS1 | TIRAP, IRAK, p65/RelA | K48 | Proteolytic degradation | PDLIM2 | P65/RelA | K48 | Proteolytic degradation | COMMD1 | P65/RelA | K48 | Proteolytic degradation | TRIM27 | IKKα, IKKβ | K48 | Proteolytic degradation | TRIM38 | TRAF6, TRIF, TAB2/3 | K48 | Proteolytic degradation |
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