Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling

Table 3

Negative regulators of TLR signaling involved in deubiquitination.

dUb	Target molecules	Ubiquitin-mediated modifications	Biological function
A20	RIP1, RIP2, TRAF2, TRAF6, MALT1, NEMO	K63	Signaling termination
CYLD	MyD88, TRAF2, TRAF6, TRAF7, RIP1, NEMO	K63	Signaling termination
USP2α	TRAF6	K63	Signaling termination
USP4	TRAF2, TRAF6, TAK1	K63	Signaling termination
USP7	TRAF6, NEMO	K63	Signaling termination
USP10	TRAF6, NEMO	K63/M1	Signaling termination
USP11	IκB	K48	Proteolytic degradation
USP15	IκB	K48	Proteolytic degradation
USP18	TAK1, NEMO	K63	Signaling termination
USP21	RIP1	K63	Signaling termination
USP25	TRAF2, TRAF3, TRAF5, TRAF6	K63/K48	Signaling termination/proteolytic degradation