Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

Figure 1

Analysis of Tofa-DCs surface phenotype by flow cytometry. (a) Tofa-pretreated DCs were cultured in the presence or in the absence of LPS (100 ng/mL) for 24 hours. Surface expressions of CD11c, CD83, CD40, CD80, and CD86 on DCs were analyzed by flow cytometry. (b) The frequencies of CD83, CD40, CD80, or CD86 positive cells were determined. The representative results of three independent experiments with similar findings are shown. Statistical testing was performed using the Mann-Whitney test. Data are means ± SEM, , and .

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