Evaluation of Multiple Immunoassay Technology Platforms to Select the Anti-Drug Antibody Assay Exhibiting the Most Appropriate Drug and Target Tolerance

Figure 6

Evaluation of target interference for each assay in the presence of 0, 5, 20, 50, and 200 ng/mL of soluble dimeric target evaluated in the method without acid dissociation or target depletion. The noise represents the mean NC signal measured in each method. The dotted line represents the threshold fixed at a signal/noise value equal to 1.25.