Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis

Figure 1

The sublingual immunotherapy alters the signaling of type I interferons in patients with seasonal allergic rhinitis. (a) The principal component analysis (PCA) plot gives an overview of the differentially expressed genes in patients before and one year after treatment as well as healthy controls. (b) The workflow of the selection of putative genes regulated by SLIT. (c) GO term enrichment of genes reacting to SLIT treatment using AMIGO. The numbers in the bars represent numbers of genes identified for each term. The value comes from the comparison of patients before SLIT and after one year of SLIT in step 3 in (b). Red line is value 0.05 (− = 1.3).

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