Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis

Figure 2

Sublingual immunotherapy causes complex changes of the key genes of the interferon pathway. (a) The diagrammatic sketch of potential involvement of type I interferons in T cell differentiation and sublingual immunotherapy. (b) The comparison of expression of upstream regulators, STAT1, STAT2, IFNα, IFNβ, and IFNG, in the diluent- and allergen-challenged cells of healthy controls and patients before treatment, after one year of SLIT, and after two years SLIT. Results are presented as –log ( value). The value comes from the Fisher exact test done between the different comparisons for that particular gene significance. (c) The activation Z-score of expression of upstream regulators, STAT1, STAT2, IFNα, IFNβ, and IFNG, in the diluent- and allergen-challenged cells of healthy controls and patients before treatment, after one year of SLIT, and after two years of SLIT.

(a)

(b)

(c)