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Journal of Immunology Research
Volume 2016, Article ID 5183686, 9 pages
http://dx.doi.org/10.1155/2016/5183686
Clinical Study

The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation

1Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
2West China School of Public Health, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, China
3Department of Rheumatology, Jinjiang District People’s Hospital of Chengdu City, Chengdu, China
4ICU, West China Hospital, Sichuan University, Chengdu, China

Received 12 June 2016; Revised 2 September 2016; Accepted 8 September 2016

Academic Editor: Selena Vigano

Copyright © 2016 Liuye Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Systemic lupus erythematosus (SLE) is an autoimmune disease identified by a plethora of production of autoantibodies. Autoreactive T cells may play an important role in the process. Attenuated T cell vaccination (TCV) has proven to benefit some autoimmune diseases by deleting or suppressing pathogenic T cells. However, clinical evidence for TCV in SLE is still limited. Therefore, this self-controlled study concentrates on the clinical effects of TCV on SLE patients. Methods. 16 patients were enrolled in the study; they accepted TCV regularly. SLEDAI, clinical symptoms, blood parameters including complements 3 and 4 levels, ANA, and anti-ds-DNA antibodies were tested. In addition, the side effects and drug usage were observed during the patients’ treatment and follow-up. Results. Remissions in clinical symptoms such as facial rash, vasculitis, and proteinuria were noted in most patients. There are also evident reductions in SLEDAI, anti-ds-DNA antibodies, and GC dose and increases in C3 and C4 levels, with no pathogenic side effects during treatment and follow-up. Conclusions. T cell vaccination is helpful in alleviating and regulating systemic lupus erythematosus manifestation.