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Journal of Immunology Research
Volume 2016, Article ID 5380792, 8 pages
http://dx.doi.org/10.1155/2016/5380792
Research Article

Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients

1Department of Dermatology and Venereology, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic
2Institute of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic
3Department of Transfusion Medicine, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic
4Department of Medical Biophysics, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic
5Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic
6Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic

Received 13 September 2016; Revised 11 November 2016; Accepted 30 November 2016

Academic Editor: Margarete D. Bagatini

Copyright © 2016 Simona Vachatova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis. The study is based on the comparison between the group of psoriatic patients (74) and the control group (65). We found significantly higher BMI () and diastolic blood pressure () in the psoriatic patients. The values of waist circumference and BMI were significantly higher () in the male patients compared to the men in the control group. The analysis revealed significantly higher CRP (), Lp-PLA2 (), leptin (), and resistin () levels in the psoriatic patients. Significantly higher levels of CRP (), Lp-PLA2 (), leptin (), and resistin () were found in the patients with MS compared to the controls with MS. The level of adiponectin was significantly lower () in the patients with MS. Finally, we found significantly higher level of Lp-PLA2 () in the group of patients without MS compared to the controls without MS. In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis. The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.