Immunomodulatory Effects of 1,25-Dihydroxyvitamin D<sub>3</sub> on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens

<div>Experimental design. CD14+ monocytes were cultured for 6 days in the presence of IL-4 and GM-CSF or in the presence of IL-4, GM-CSF, and 1,25(OH)<sub>2</sub>D<sub>3</sub> to obtain immature conventional DC (iDC) or 1,25(OH)<sub>2</sub>D<sub>3</sub>-treated iDC, respectively. On day 6, iDC were stimulated with a cocktail of proinflammatory cytokines (i.e., cc-matured DC (cc-mDC)) or with LPS and IFN-<i>γ</i> (i.e., LPS-matured DC (LPS-mDC)) or left untreated (i.e., iDC).</div>

Journal of Immunology Research

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Figure 1

Figure 1: Immunomodulatory Effects of 1,25-Dihydroxyvitamin D<sub>3</sub> on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens 

Figure 1 | Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens 