Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews

Figure 5

Mean difference (95% confidence intervals) for Tol-DC in combination with IS versus IS alone for allografts survival in heart (a), small intestine (b), islet (c), and skin (d) transplantation models. Rats used in study Gorczynski 1998 [8] in small intestine and skin models were MHC semimismatch. In the footnotes, “−” before “DC” means genetic modification and “+” inside the parentheses means substances added in the culture medium and “+” outside the parentheses means combined IS agents. If not specialized, DC refers to donor bone borrow DC.

(a) Heart transplantation

(b) Small intestine transplantation in rats

(c) Islet transplantation

(d) Skin transplantation