Review Article
Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews
Table 3
Effects of Tol-DC alone and Tol-DC in combination with IS on allografts survival. Values are mean difference (95% confidence intervals).
| | Transplantation models | Animal models | Tol-DC versus untreated | statistic | index | Tol-DC + IS versus Tol-DC | statistic | index | Tol-DC + IS versus IS | statistic | index |
| | Liver Tx | Rats | 18.17 (11.02 to 25.33) | | High (95%) | NA | NA | NA | NA | NA | NA |
| | Renal Tx | Rats | 17.72 (13.35 to 22.10) | | High (99%) | NA | NA | NA | NA | NA | NA |
| | Heart Tx | Rats | 14.21 (6.11 to 22.31) | | High (100%) | 60.21 (−43.78 to 164.20) | | High (100%) | 57.56 (−59.15 to 174.27) | | High (100%) | | Mice | 11.61 (7.73 to 15.49) | | High (99%) | 5.05 (1.53 to 8.57) | | High (91%) | 1.72 (−3.67 to 7.10) | | High (93%) | | Total | 12.78 (8.30 to 17.26) | | High (100%) | 31.47 (−33.22 to 96.16) | | High (100%) | 34.67 (−24.09 to 93.42) | | High (100%) |
| | Small intestine Tx | Rats | 8.89 (6.16 to 11.61) | | High (87%) | — | — | — | 8.97 (−3.75 to 21.07) | | High (99%) |
| | Islet Tx | Rats | 7.28 (−2.91 to 17.46) | | High (98%) | 137.49 (96.59 to 178.40) | | Low (0%) | 177.83 (160.05 to 195.62) | | Low (33%) | | Mice | 6.81 (2.97 to 10.64) | | High (70%) | NA | NA | NA | NA | NA | NA | | Total | 7.70 (1.49 to 13.92) | | High (97%) | 108.21 (46.57 to 169.86) | | High (82%) | 133.26 (34.64 to 231.88) | | High (100%) |
| | Skin Tx | Mice | 5.45 (2.31 to 8.59) | | High (94.7%) | 3.84 (3.40 to 4.29) | | Low (34%) | 0.45 (0.00 to 0.89) | | Low (35%) | | Rats | — | — | — | — | — | — | 7.15 (−3.84 to 18.13) | | High (93%) | | Total | — | — | — | — | — | — | 4.03 (−1.60 to 9.65) | | High (92%) |
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—: no data. NA: not applicable. Only one set of data in the subgroup.
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