Review Article
Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?
Table 2
Function of T
-related molecules during T
migration and interaction at the T/B border.
| | T cell molecule | Ligand | Function in mice | Function in humans |
| | CXCR5 | CXCL13 | CXCR5 induction is necessary for T cell homing to the follicles [135] | T cells localized into B cell follicles express CXCR5 and provide B cell help [136, 137] |
| | CCR7 | CCL19/CCL20 | Maintenance of CCR7 expression impedes the entry of T cells on the follicles [135] | CXCR5+CD4+ T cells loose CCR7 expression in SLO [136, 137] |
| | ICOS | ICOSL | CD4+ T cells fail to develop in T and to promote optimal GC responses when follicular B cells do not express ICOSL [75] | ND |
| | SAP | SLAM | CD4+ T cells from SAPā/ā mice are unable to stably interact with cognate B cells [32] | XLP patients display reduced T numbers and no mem B cells [33] |
|
|
GC: germinal center; SLO; second lymphoid organs; XLP: X-linked lymphoproliferative disease; ND: not determined; mem B cells: memory B cells.
|
